Material Safety Data Sheet (MSDS): Phosphanol

Identification

Product Name: Phosphanol
Synonyms: Diphosphanyl alcohol, Hydroxyphosphine
Chemical Formula: C2H7OP
Recommended Use: Industrial synthesis, chemical intermediate
Manufacturer Details: Global Synthesis Inc., Industrial Park, Houston, TX, USA
Emergency Contact: CHEMTREC: 1-800-424-9300
CAS Number: 1234-56-7
UN Number: 3264
Product Code: GSP-0501

Hazard Identification

GHS Classification: Acute Toxicity, Category 3 (oral, dermal), Skin Corrosion, Category 1B, Serious Eye Damage, Category 1
Label Elements: Danger — Toxic if swallowed, severe skin burns and eye damage
Hazard Statements: Ingestion or inhalation may be fatal, causes severe burns to skin and eyes, may irritate respiratory tract, prolonged exposure damages mucous membranes
Precautionary Statements: Keep locked up, use with adequate ventilation, protective gear required, avoid breathing vapor, prevent release to the environment
Signal Word: DANGER
Routes of Exposure: Ingestion, inhalation, skin, eyes
Target Organs: Gastrointestinal tract, skin, eyes, lungs

Composition / Information on Ingredients

Chemical Name: Phosphanol
Concentration: 99% w/w
Impurities: ≤1% (includes traces of organophosphorus compounds, water)
Molecular Weight: 78.05 g/mol
Other Ingredients: No additives or stabilizers

First Aid Measures

Inhalation: Move affected person into fresh air, support breathing with oxygen, seek immediate medical attention
Skin Contact: Quickly remove contaminated clothes, flush skin with running water for at least 20 minutes, wash with mild soap, get emergency medical care
Eye Contact: Rinse opened eye for minimum 20 minutes, remove contact lenses if possible, keep eyelids open, call emergency services
Ingestion: Do not induce vomiting, rinse mouth, drink small sips of water if conscious, obtain urgent hospital care
Most Important Symptoms: Chemical burns, irritation, nausea, headache, respiratory distress, risk of shock

Fire-Fighting Measures

Suitable Extinguishing Media: Dry powder, foam, or carbon dioxide for small fires
Unsuitable Media: Water jets may spread material or cause reactivity
Hazardous Combustion Products: Toxic phosphorus oxides, carbon monoxide
Special Protective Equipment: Full-body suit, self-contained breathing apparatus
Advice for Firefighters: Approach upwind, keep containers cooled, avoid contact with skin and inhalation of smoke

Accidental Release Measures

Personal Precautions: Evacuate area, ventilate, wear chemical-resistant gloves, goggles, respiratory protection
Environmental Precautions: Prevent leakage into drains, soil, or waterways, alert local authorities if large spill occurs
Containment & Cleanup Methods: Use inert absorbent (vermiculite, sand), collect in non-metallic containers, neutralize residue with dilute sodium bicarbonate, dispose by licensed chemical waste handler
Decontamination: Wash spill area with copious water and detergent after cleanup

Handling and Storage

Handling: Use chemical fume hood, keep containers tightly closed, avoid splashing or generation of aerosol, never handle without protective gear
Storage Conditions: Store in cool, dry, well-ventilated area, separate from oxidizers and acids
Container Materials: Use corrosion-resistant, tightly sealed containers
Incompatibilities: Strong acids, alkali metals, strong oxidizers, halogens
Storage Temperature: Keep below 25°C, protect from moisture and direct sunlight

Exposure Controls and Personal Protection

Occupational Exposure Limits: OSHA PEL: 0.1 ppm, ACGIH TLV: 0.1 ppm
Engineering Controls: Local exhaust ventilation, emergency eyewash stations, chemical safety showers
Personal Protective Equipment: Chemical-resistant nitrile gloves, splash goggles, faceshield, flame-resistant laboratory coat, closed shoes
Respiratory Protection: Full-face respirators with organic vapor cartridges
Hygiene Measures: Wash hands thoroughly after handling, do not eat or drink in work area, remove and wash contaminated clothing before reuse

Physical and Chemical Properties

Appearance: Clear, colorless to pale yellow liquid
Odor: Sharp, irritating, garlic-like
pH (1% solution): 4.1
Flash Point: 28°C (closed cup)
Boiling Point: 173°C
Melting Point: -42°C
Solubility in Water: Miscible
Vapor Pressure: 12 mmHg at 20°C
Density: 1.13 g/cm³ at 20°C
Viscosity: 0.89 mPa·s at 25°C
Auto-ignition Temperature: 265°C
Explosive Limits: 1.4–9.6% (v/v) in air

Stability and Reactivity

Chemical Stability: Stable under recommended storage and handling conditions
Hazardous Reactions: Violent reaction with strong oxidizers, releases toxic phosphine gas with alkali metals
Conditions to Avoid: High temperatures, incompatible chemicals, direct sunlight, moisture
Decomposition Products: Phosphine, phosphorus oxides, carbon monoxide, formaldehyde
Polymerization: Not expected under normal conditions

Toxicological Information

Acute Toxicity: LD50 (oral, rat): 12 mg/kg; LD50 (dermal, rabbit): 55 mg/kg
Inhalation: Causes irritation, headache, nausea, bronchospasm; severe exposure leads to pulmonary edema, death
Skin Contact: Rapid absorption, produces burns and blisters
Eye Contact: Causes conjunctivitis, corneal damage, eventual blindness if not rinsed
Chronic Exposure: Risk of liver, kidney, and nervous system injury after repeated contact
Carcinogenicity: Not classified according to IARC; no adequate animal or human data
Mutagenicity: No known mutagenic potential
Sensitization: Prolonged exposure may cause dermatitis or respiratory sensitization

Ecological Information

Aquatic Toxicity: Very toxic to aquatic organisms (LC50 <1 mg/L for fish over 96 h)
Persistence and Degradability: Slow decomposition in soil; forms stable organophosphorus residues
Bioaccumulative Potential: Moderate risk, possible accumulation in aquatic plants and animals
Mobility: High solubility in water, moderate mobility through soils
Additional Information: Do not release into sewage or surface water; large spills threaten aquatic and soil ecosystems

Disposal Considerations

Disposal Methods: Transfer waste to approved chemical incineration facility; follow local regulations
Contaminated Packaging: Triple-rinse containers, puncture, tag for hazardous waste disposal
Prohibited Disposal: Do not pour down drain or landfill untreated
Regulatory Disposal Codes: US EPA Hazardous Waste Code P107; consult local, regional, national laws

Transport Information

UN Number: 3264
Proper Shipping Name: Corrosive liquid, acidic, organic, n.o.s. (contains Phosphanol)
Hazard Class: 8 (Corrosive)
Packing Group: II
Marine Pollutant: Yes
DOT Label: CORROSIVE
Special Transport Measures: Use corrosion-resistant containers, keep upright at all times, mark with hazard label and emergency contact

Regulatory Information

TSCA Status: Listed
SARA 313: Subject to reporting
REACH Registration No.: 01-9999999-84-0000
OSHA Hazard Communication: Classified as hazardous
Canadian WHMIS: Class D1A (very toxic), E (corrosive)
EU Classification: T+ (very toxic), C (corrosive)
Inventory Listings: US TSCA, EU EINECS, Canada DSL
R-phrases: R25 (toxic if swallowed), R34 (causes burns)
S-phrases: S7/8 (keep container tightly closed and dry), S26 (in case of eye contact, rinse immediately), S36/37/39 (wear suitable protective clothing, gloves, and eye/face protection)