Material Safety Data Sheet (MSDS) for N-Isopropyl-N'-phenyl-p-phenylenediamine (IPPD)

Identification

Chemical Name: N-Isopropyl-N'-phenyl-p-phenylenediamine
Synonyms: IPPD, 4010 NA, Antioxidant 4010NA
Chemical Formula: C15H18N2
CAS Number: 101-72-4
Recommended Use: Used in the rubber industry as an antioxidant and antiozonant
Manufacturer Contact Information: Emergency phone, supplier name, and address typically go here based on supplier
Product Code: Specific company code as labeled

Hazard Identification

GHS Classification: Acute toxicity (oral, category 4), skin sensitizer (category 1), aquatic chronic toxicity (category 2)
Signal Word: Warning
Hazard Statements: Harmful if swallowed, may cause an allergic skin reaction, toxic to aquatic life with long lasting effects
Precautionary Statements: Avoid release to environment, avoid breathing dust or particles, use personal protective equipment as required, wash thoroughly after handling
Hazard Symbols: Exclamation mark, environment
Emergency Overview: Blackish-brown to violet powder, slight amine odor, potentially harmful if inhaled, ingested, or in contact with skin

Composition / Information on Ingredients

Chemical: N-Isopropyl-N'-phenyl-p-phenylenediamine
CAS Number: 101-72-4
Concentration: Typically ranges from 96 - 99% pure
Impurities: Trace levels of related isomers, byproducts from manufacturing process

First Aid Measures

Inhalation: Move affected person to fresh air, provide oxygen if breathing is difficult, seek medical attention if symptoms persist
Skin Contact: Remove contaminated clothing, wash skin with soap and water for at least 15 minutes, seek medical help if irritation or sensitization develops
Eye Contact: Immediately flush eyes with plenty of water for a minimum of 15 minutes, remove contact lenses if worn, get medical attention
Ingestion: Rinse mouth with water, do not induce vomiting unless directed by medical personnel, call poison control or doctor right away
Most Important Symptoms: May cause redness, itching, rash, allergic reaction, headache, nausea if significant exposure occurs
Advice for Physicians: Treat symptomatically, monitor for allergic reaction

Fire-Fighting Measures

Suitable Extinguishing Media: Dry chemical, CO2, foam, or water spray can be used
Unsuitable Extinguishing Media: Strong water jets may spread the material
Specific Hazards: Decomposition releases toxic fumes like nitrogen oxides, carbon monoxide, and aniline derivatives
Protective Equipment: Firefighters need self-contained breathing apparatus and full protective gear
Fire-fighting Instructions: Avoid breathing fumes, keep containers cool with water spray if exposed to fire, contain runoff

Accidental Release Measures

Personal Precautions: Wear gloves, goggles, dust mask, and avoid breathing dust or contact with skin
Environmental Precautions: Prevent runoff to sewers, waterways, or soil
Containment Methods: Gather spilled powder using non-sparking tools, place in closed containers for disposal
Clean-up Procedures: Ventilate area, use vacuum with HEPA filter or damp material to reduce dust, avoid dry sweeping

Handling and Storage

Handling: Avoid creating dust, use only with local exhaust or adequate ventilation, prevent skin and eye contact by wearing protective gear
General Hygiene: Wash hands and face after handling, do not eat, drink, or smoke in processing areas
Storage Conditions: Store tightly closed in a cool, dry, well-ventilated location, keep away from oxidizers and acids
Incompatible Materials: Strong oxidizing agents, strong acids, avoid heat and sources of ignition
Specific End Use: Additive in rubber processing, especially tires, belts, hoses

Exposure Controls and Personal Protection

Exposure Limits: No established OSHA or ACGIH limits, keep exposure as low as practical
Engineering Controls: Local exhaust ventilation, process enclosures, general room ventilation
Personal Protective Equipment: Chemical-resistant gloves (nitrile or neoprene), tight-fitting goggles, dust respirator or PAPR if dust exceeds safe levels, lab coats or chemical aprons
Environmental Controls: Avoid release to drains or environment

Physical and Chemical Properties

Appearance: Dark brown to violet crystalline powder
Odor: Slight amine-like odor
Odor Threshold: Not available
pH: Not applicable (insoluble in water)
Melting Point: 87–100°C (varies by source)
Boiling Point: Decomposes before boiling
Flash Point: 200°C (open cup method)
Evaporation Rate: Not available
Flammability: Not highly flammable, but will burn
Vapor Pressure: Near zero at 20°C
Solubility: Insoluble in water, soluble in organic solvents like acetone, benzene, and toluene
Vapor Density: Not available
Specific Gravity: 1.12–1.20
Partition Coefficient (log Pow): About 2.9–3.4
Decomposition Temperature: Above 200°C
Auto-ignition Temperature: Above 300°C, specific numbers vary
Viscosity: Not applicable

Stability and Reactivity

Chemical Stability: Stable under normal storage and handling conditions
Reactivity: Not highly reactive, but can react with strong oxidizers
Hazardous Reactions: Avoid contact with acids, strong oxidizers, and excessive heat
Decomposition Products: Nitrogen oxides, carbon monoxide, carbon dioxide, aniline; toxic under fire or thermal decomposition
Polymerization: Will not occur under recommended handling conditions

Toxicological Information

Acute Toxicity: Oral LD50 in rats about 600 mg/kg
Skin Sensitization: Skin rashes, allergic reactions in sensitive individuals; repeated or prolonged contact increases risk
Inhalation: Dust can irritate respiratory tract, cause coughing, headache, nausea
Eye Effects: May cause redness, watering, stinging
Chronic Exposure: Repeated long-term exposure linked to skin sensitization and possibly cancer in some animal studies
Mutagenicity/Carcinogenicity: Animal studies show equivocal evidence, not classified as carcinogenic to humans by IARC or NTP
Other Effects: No evidence of teratogenicity or reproductive toxicity in standard assays

Ecological Information

Environmental Fate: Not readily biodegradable, persistent in soil and water
Aquatic Toxicity: Harmful to fish and aquatic invertebrates, EC50 (48 hr) for Daphnia about 1–10 mg/L
Bioaccumulation: Potential moderate bioaccumulation due to log Pow values
Mobility: Binds to soil, low mobility in water
Other Hazards: Degradation produces aniline, which is also toxic to aquatic life

Disposal Considerations

Waste Disposal Methods: Dispose of unused material, contaminated packaging, and cleanup residues through licensed hazardous waste disposal contractors
Regulations: Comply with national, regional, and local environmental control regulations
Handling Waste: Keep in closed, labeled containers; do not allow spills to enter drains or waterways
Special Precautions: Avoid burning or landfill disposal unless approved by authorities

Transport Information

UN Number: Not regulated for transport in most countries when shipped as manufactured
Proper Shipping Name: Not specifically listed, usually shipped as chemical product, not dangerous for most transport
Transport Hazard Class: Not classified as hazardous
Packing Group: Not assigned
Environmental Hazards: Not a marine pollutant under IMO, but best practice keeps away from aquatic releases
Special Precautions During Transport: Prevent dust dispersion, store away from food and feed, ensure packages are secure and upright

Regulatory Information

TSCA Status: Listed on US Toxic Substances Control Act inventory
REACH Status: Registered under European Chemicals Agency
China IECSC: Listed
Canadian DSL: Listed
California Proposition 65: Not listed as causing cancer or reproductive harm as of current listings
Other Regulations: Refer to OSHA, EPA, EU Directives, and local chemical safety acts for worker safety and environmental protection requirements
Labeling Requirements: GHS and local system must be followed on labels and packaging